Factor XI Deficiency
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NORD is very grateful to Paula H. B. Bolton-Maggs, BMBCh, DM, FRCP, FRC Path, Department of Clinical Haematology, Manchester Royal Infirmary, United Kingdom, for assistance in the preparation of this report.
Synonyms of Factor XI Deficiency
- haemophilia C
- hemophilia C
- plasma thromboplastin antecedent deficiency
- PTA deficiency
- Rosenthal syndrome
- No subdivisions found.
Factor XI deficiency is a rare genetic bleeding disorder caused by reduced levels and insufficient activity of a blood protein called factor XI. Factor XI is a clotting factor. Clotting factors are specialized proteins that are essential for proper clotting, the process by which blood solidifies like glue to plug the site of a wound to stop bleeding. Individuals with factor XI deficiency do not bleed faster or more profusely than healthy individuals, but, because their blood clots poorly, they may have difficulty stopping the flow of blood from a deep or surgical wound. This may be referred to as prolonged bleeding or a prolonged bleeding episode. The severity of factor XI deficiency can vary from one person to another. In many cases, prolonged bleeding episodes only occur after surgery, dental procedures or trauma. Bleeding tendencies in factor XI deficiency are unpredictable and inconsistent, making the disorder difficult to manage in some cases. Factor XI deficiency is caused by disruptions or changes (mutations) to the F11 gene. Factor XI deficiency is inherited autosomally and can occur in people of either sex.
Factor XI deficiency was first described in the medical literature in 1953. It used to be also referred to as hemophilia C in order to distinguish it from the better known hemophilia types A and B. In rare cases, factor XI deficiency can be acquired during life (acquired factor XI deficiency). This report deals with the genetic form. Although the genetic form is present at birth, as it is a mild bleeding disorder symptoms do not usually occur until later in life.
Factor XI Deficiency Resources
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