You are reading a NORD Rare Disease Report Abstract. NORD’s full collection of reports on over 1200 rare diseases is available to subscribers (click here for details). We are now also offering two full rare disease reports per day to visitors on our Web site.
NORD is very grateful to N.J. Gutowski, MD, Consultant Neurologist and Senior Lecturer, Royal Devon and Exeter Hospital and Peninsula Medical School, UK, for assistance in the preparation of this report.
Synonyms of Duane syndrome
- DR syndrome
- Duane radial ray syndrome (DRRS)
- Duane's retraction syndrome
- eye retraction syndrome
- retraction syndrome
- Stilling-Turk-Duane syndrome
- Duane syndrome Type 2A, 2B, 2C
- Duane syndrome Type 3A, 3B, 3C
- Duane syndrome Type IA, 1B, 1C
Duane syndrome (DS) is an eye movement disorder present at birth (congenital) characterized by horizontal eye movement limitation [a limited ability to move the eye inward toward the nose (adduction), outward toward the ear (abduction), or in both directions]. In addition, when the affected eye(s) moves inward toward the nose, the eyeball retracts (pulls in) and the eye opening (palpebral fissure) narrows. In some cases, when the eye attempts to look inward, it moves upward (upshoot) or downward (downshoot).
Duane syndrome falls under the larger heading of strabismus (misalignment of the eyes) under the subclassification of incomitant strabismus (misalignment of the eyes that varies with gaze directions) and subheading of what was previously termed extraocular fibrosis syndromes (conditions associated with fibrosis of the muscles that move the eyes), now termed Congenital Cranial Dysinnervation Disorders (CCDDs). The CCDDs are a group of congenital neuromuscular diseases resulting from developmental errors in innervation, the abnormalities involve one or more cranial nerves/nuclei with absence of normal innervation and/or secondary aberrant innervation. The group includes Duane syndrome, congenital fibrosis of the extraocular muscles (CFEOM), congenital ptosis, Marcus Gunn Jaw winking, Möbius syndrome, Crocodile tears, horizontal gaze palsy and congenital facial palsy, but this is not an exhaustive list.
Duane syndrome has been subdivided clinically into three types: Type 1, Type 2, and Type 3.
Organizations related to Duane syndrome
Further information can be found at the reviewer's web page: http://www.rdehospital.nhs.uk/prof/molecular_genetics/default.html
The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.
The National Organization for Rare Disorders (NORD) web site, its databases, and the contents thereof are copyrighted by NORD. No part of the NORD web site, databases, or the contents may be copied in any way, including but not limited to the following: electronically downloading, storing in a retrieval system, or redistributing for any commercial purposes without the express written permission of NORD. Permission is hereby granted to print one hard copy of the information on an individual disease for your personal use, provided that such content is in no way modified, and the credit for the source (NORD) and NORD’s copyright notice are included on the printed copy. Any other electronic reproduction or other printed versions is strictly prohibited.
Copyright 1986, 1990, 1994, 1996, 2000, 2009, 2012
NORD's Rare Disease Information Database is copyrighted and may not be published without the written consent of NORD.