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Duane syndrome

Abstract

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NORD is very grateful to N.J. Gutowski, MD, Consultant Neurologist and Senior Lecturer, Royal Devon and Exeter Hospital and Peninsula Medical School, UK, for assistance in the preparation of this report.

Synonyms of Duane syndrome

DR syndrome
Duane radial ray syndrome (DRRS)
Duane's retraction syndrome
eye retraction syndrome
retraction syndrome
Stilling-Turk-Duane syndrome

Disorder Subdivisions

Duane syndrome Type 2A, 2B, 2C
Duane syndrome Type 3A, 3B, 3C
Duane syndrome Type IA, 1B, 1C

General Discussion

Duane syndrome (DS) is an eye movement disorder present at birth (congenital) characterized by horizontal eye movement limitation [a limited ability to move the eye inward toward the nose (adduction), outward toward the ear (abduction), or in both directions]. In addition, when the affected eye(s) moves inward toward the nose, the eyeball retracts (pulls in) and the eye opening (palpebral fissure) narrows. In some cases, when the eye attempts to look inward, it moves upward (upshoot) or downward (downshoot).

Duane syndrome falls under the larger heading of strabismus (misalignment of the eyes) under the subclassification of incomitant strabismus (misalignment of the eyes that varies with gaze directions) and subheading of what was previously termed extraocular fibrosis syndromes (conditions associated with fibrosis of the muscles that move the eyes), now termed Congenital Cranial Dysinnervation Disorders (CCDDs). The CCDDs are a group of congenital neuromuscular diseases resulting from developmental errors in innervation, the abnormalities involve one or more cranial nerves/nuclei with absence of normal innervation and/or secondary aberrant innervation. The group includes Duane syndrome, congenital fibrosis of the extraocular muscles (CFEOM), congenital ptosis, Marcus Gunn Jaw winking, Möbius syndrome, Crocodile tears, horizontal gaze palsy and congenital facial palsy, but this is not an exhaustive list.

Duane syndrome has been subdivided clinically into three types: Type 1, Type 2, and Type 3.

Organizations related to Duane syndrome

Further information can be found at the reviewer's web page: http://www.rdehospital.nhs.uk/prof/molecular_genetics/default.html

Cleft Lip and Palate Foundation of Smiles
- 2044 Michael Ave SW
- Wyoming, MI 49509
- Phone #: 616-329-1335
- 800 #: N/A
- e-mail: Rachelmancuso09@comcast.net
- Home page: http://www.cleftsmile.org
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Phone #: 301-251-4925
- 800 #: 888-205-2311
- e-mail: N/A
- Home page: http://rarediseases.info.nih.gov/GARD/
Let Them Hear Foundation
- 1900 University Avenue, Suite 101
- East Palo Alto, CA 94303
- Phone #: 650-462-3174
- 800 #: N/A
- e-mail: info@letthemhear.org
- Home page: http://www.letthemhear.org
March of Dimes Birth Defects Foundation
- 1275 Mamaroneck Avenue
- White Plains, NY 10605
- Phone #: 914-997-4488
- 800 #: 888-663-4637
- e-mail: Askus@marchofdimes.com
- Home page: http://www.marchofdimes.com
MUMS National Parent-to-Parent Network
- 150 Custer Court
- Green Bay, WI 54301-1243 USA
- Phone #: N/A
- 800 #: N/A
- e-mail: mums@netnet.net
- Home page: http://www.netnet.net/mums/
NIH/National Eye Institute
- 31 Center Dr
- MSC 2510
- Bethesda, MD 20892-2510 United States
- Phone #: 301-496-5248
- 800 #: --
- e-mail: 2020@nei.nih.gov
- Home page: http://www.nei.nih.gov/
NIH/Office of Rare Disease Research
- 6100 Executive Boulevard Room 3A07, MSC 7518
- Bethesda, MD 20892-7518
- Phone #: 301-402-4336
- 800 #: --
- e-mail: ordr@od.nih.gov
- Home page: http://rarediseases.info.nih.gov
Schepens Eye Research Institute
- 20 Staniford Street
- Boston, MA 02114-2500
- Phone #: 617-912-0100
- 800 #: --
- e-mail: richard.godfrey@schepens.harvard.edu
- Home page: http://www.theschepens.org/

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