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Lambert-Eaton Myasthenic Syndrome

Abstract

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NORD is very grateful to Paul Gozzard, MRCP, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK, for assistance in the preparation of this report.

Synonyms of Lambert-Eaton Myasthenic Syndrome

  • Eaton-Lambert syndrome
  • Lambert-Eaton syndrome
  • LEMS
  • myasthenic syndrome of Lambert-Eaton

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder characterized by the gradual onset of muscle weakness, especially of the pelvic and thigh muscles. Approximately 60 percent of LEMS cases are associated with a small cell lung cancer (SCLC), and the onset of LEMS symptoms often precedes the detection of the cancer. The LEMS patients with cancer tend to be older and nearly always have a long history of smoking. In cases in which there is no associated cancer, disease onset can be at any age.

Organizations related to Lambert-Eaton Myasthenic Syndrome

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