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Chandler's Syndrome

Abstract

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NORD is very grateful to M. Bruce Shields, MD, Marvin L. Sears Professor and Chairman Emeritus, Department of Ophthalmology & Visual Science, Yale University School of Medicine, Yale Eye Center, for assistance in the preparation of this report.

Synonyms of Chandler's Syndrome

  • iridocorneal endothelial syndrome
  • iris atrophy with corneal edema and glaucoma

Disorder Subdivisions

  • No subdivisions found.

General Discussion

Chandler's syndrome (CS) is a rare eye disorder in which the endothelium, the single layer of cells lining the interior of the cornea, proliferates causing distortion of the iris, corneal edema, and unusually high pressure in the eye (glaucoma). CS is one of three syndromes affecting the eyes (progressive iris atrophy and Cogan-Reese syndrome are the other two) that make up the iridocorneal endothelial syndrome. Chandler's syndrome affects females more often than males and usually presents in young adulthood to middle age.

Most often the condition affects one eye only but the fellow eye often has subclinical involvement. The combination of high pressure within the eye (glaucoma) and corneal edema can result in reduced vision with pain.

Organizations related to Chandler's Syndrome

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