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Berylliosis

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Synonyms of Berylliosis
  • Acute Beryllium Disease
  • Beryllium Granulomatosis
  • Beryllium Pneumonosis
  • Beryllium Poisoning

Disorder Subdivisions

  • Acute Berylliosis (Acute Beryllium Disease)
  • Chronic Berylliosis (Chronic Beryllium Disease [CBD])


General Discussion
Berylliosis is a form of metal poisoning caused by inhalation of beryllium dusts, vapors, or its compounds or implantation of the substance in the skin. The toxic effects of beryllium most commonly occur due to occupational exposure. Beryllium is a metallic element used in many industries, including electronics, high-technology ceramics, metals extraction, and dental alloy preparation.

There are two forms of beryllium-induced lung disease: acute and chronic. Acute berylliosis has a sudden, rapid onset and is characterized by severe inflammation of the lungs (pneumonitis), coughing, increasing breathlessness (dyspnea), and other associated symptoms and findings. In addition, in some individuals, the skin or the eyes may be affected. The more common, chronic form of the disease develops more slowly and, in some cases, may not become apparent for many years after initial beryllium exposure. Chronic berylliosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) within certain tissues and organs and widespread scarring and thickening of deep lung tissues (interstitial pulmonary fibrosis). Although granuloma development primarily affects the lungs, it may also occur within other bodily tissues and organs, such as the skin and underlying (subcutaneous) tissues or the liver. In individuals with chronic berylliosis, associated symptoms and findings often include dry coughing, fatigue, weight loss, chest pain, and increasing shortness of breath.
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Organizations related to Berylliosis
  • American Lung Association
    1301 Pennsylvania Ave. NW
    Washington DC 20004
    Phone #: 202-785-3355
    800 #: 800-586-4872
    e-mail: info@lungusa.org
    Home page: http://www.lungusa.org
  • Centers for Disease Control and Prevention
    1600 Clifton Road
    Atlanta GA 30333
    Phone #: 404-639-3534
    800 #: 800-232-4636
    e-mail: cdcinfo@cdc.gov
    Home page: http://www.cdc.gov/
  • Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg MD 20898-8126
    Phone #: 301-251-4925
    800 #: 888-205-2311
    e-mail: http://rarediseases.info.nih.gov/GARD/EmailForm.aspx
    Home page: http://rarediseases.info.nih.gov/GARD
  • NIH/National Institute of Allergy and Infectious Diseases
    6610 Rockledge Drive
    MSC 6612
    Bethesda MD 20892-6612
    Phone #: 301-496-5717
    800 #: --
    e-mail: N/A
    Home page: http://www.niaid.nih.gov/

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Last modified Wednesday, November 26, 2008