Malfunctions of helicases and nucleic acid-based machines are implicated in a number of rare genetic disorders. Specifically, hereditary mutations in helicase genes are linked to rare diseases including Werner Syndrome, Bloom’s Syndrome, Rothmund-Thomson Syndrome, Cockayne Syndrome, Xeroderma Pigmentosum, Trichothiodystrophy, Warsaw Breakage Syndrome, Fanconi Anemia, Dyskeratosis Congenita, Crohn’s Disease, Ophthalmoplegia, and others. This FASEB meeting, which was first held in 2001, examines the roles of these and related helicases in genome metabolism and rare diseases. The meeting is the only one of its kind to focus on the functions, interactions and structures of helicases and helicase-like motors as components of fundamentally important supramolecular machines, and it explores their regulation and key roles in uncommon genetic disorders characterized by defects in DNA repair and genomic stability. The conference brings together a diverse group of academic and industry scientists who focus on the functional roles of helicases and helicase-like motors in pathways of nucleic acid metabolism.
Rick Russell (University of Texas at Austin)
Robert Brosh (National Institute on Aging, NIH)
and Caroline Kisker (University of Würzburg)
Special Travel Awards for Speakers Selected from Submitted Abstracts
Advanced Registration: June 5, 2019; Last Day to Register: June 29, 2019
Registration and Abstract Submission Link: https://src.faseb.org/helicases
Conference Highlights: Keynote Speaker Chris Lima and confirmed speakers including genome and nucleic acid metabolism experts Ian Hickson, James Keck, Mike O’Donnell, Pavel Janscak, Tim Lohman, James Berger, Dagmar Klostermeier, Anna Pyle, Frederic Coin, Tom Owen-Hughes, Mark Dillingham, Ralf Ficner, Eckhard Jankowsky, Brenda Bass, Steve Kowalczykowski, Brian Luke, Ralf Seidel, Vincent Croquette, Katrin Karbstein, Markus Bohnsack, Kiyoshi Nagai, Rui Zhao, Vilhelm Bohr, Bik Kwoon Tye, Virgnia Zakian, Hervé Le Hir, Kristian Baker, Lynne Maquat, Smita Patel, Karsten Weis, Beth Tran, and Katrin Paeschke.
Special Events: Women in Science Workshop, Young Investigators Workshop, and four Poster Sessions