Acquired amegakaryocytic thrombocytopenia

Disease Overview

Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent.[9867][9868] Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds.[9865][9866] There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people.[9867][9868] 

Synonyms

• Severe thrombocytopenia and selective, marked decrease or absence of megakaryocytes
• AAT
• Acquired pure megakaryocytic aplasia