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Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, a type of cancer that begins in glandular tissues. It most commonly arises in the major and minor salivary glands of the head and neck.[7974] It can also occur in the breast, uterus, or other locations in the body.[7974][7975] Symptoms depend on the tumor’s location. Salivary gland tumors may cause painless masses in the mouth or face. Tumors of the lacrimal gland may cause a bulging eye or changes in vision. Those affecting the windpipe or voice box may cause respiratory symptoms or changes in speech, respectively.[7975] Advanced tumors may cause pain and/or nerve paralysis, as ACC often spreads along the nerves.[7974][7975] It may also spread through the bloodstream. It spreads to the lymph nodes in about 5% to 10% of cases.[7974] The cause of ACC is currently unknown. It typically does not run in families. Treatment depends on many factors and may include surgery, radiation, and/or chemotherapy.[7974][7975] Unfortunately, ACC is typically an aggressive form of cancer that has a poor long-term outlook.[13517]
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