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Adrenomyeloneuropathy (AMN) is an inherited condition that affects the spinal cord. It is a form of X-linked adrenoleukodystrophy. On average, people with AMN begin to develop features in the late twenties. Signs and symptoms may include progressive stiffness and weakness of the legs; ataxia; speech difficulties; adrenal insufficiency; sexual dysfunction; and bladder control issues. Some people with AMN also have brain involvement which can lead to behavioral abnormalities, vision loss, hearing problems, and/or seizures.[8397][8399] AMN is caused by changes (mutations) in the ABCD1 gene and is inherited in an X-linked manner.[8398][8403] Treatment addresses the symptoms in each person and may include steroid replacement therapy for adrenal insufficiency.[8399][8403]
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