Arthrogryposis multiplex congenita

Print

Disease Overview

Arthrogryposis multiplex congenita (AMC) refers to the development of multiple joint contractures affecting two or more areas of the body prior to birth. A contracture occurs when a joint becomes permanently fixed in a bent or straightened position, which can impact the function and range of motion of the joint and may lead to muscle atrophy. AMC is not a specific diagnosis, but rather a physical symptom that can be associated with many different medical conditions. It is suspected that AMC is related to decreased fetal movement during development which can have a variety of different causes, including environmental factors (i.e. maternal illness, limited space), single gene changes (autosomal dominant, autosomal recessive, X-linked), chromosomal abnormalities and various syndromes. Treatment varies based on the signs and symptoms found in each person, but may include physical therapy, removable splints, exercise, and/or surgery.[8105][8106]


Synonyms

  • Arthrogryposis
  • Congenital multiple arthrogryposis
  • Fibrous ankylosis of multiple joints
  • Congenital arthromyodysplasia
  • Myodystrophia fetalis deformans
  • Guérin-Stern syndrome
  • Otto syndrome
  • Rocher-Sheldon syndrome
  • Rossi syndrome
  • Guerin-Stern syndrome

For more information, visit GARD.

National Organization for Rare Disorders