This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD).
Chromosome 10p deletion is a chromosome abnormality that occurs when there is a missing (deleted) copy of genetic material on the short arm (p) of chromosome 10. The severity and the signs and symptoms depend on the size and location of the deletion and which genes are involved. Features may affect many parts of the body and may include low birth weight, growth delay, developmental delay, low muscle tone (hypotonia), and communication difficulties. Birth defects, various medical problems, and/or distinctive facial features may also be present.
Most 10p deletions are not inherited and occur randomly during the formation of egg or sperm cells, or very early in fetal development. Some 10p deletions are present because a parent has a rearrangement of genetic material on his/her chromosomes. This rearrangement is usually a balanced translocation, which typically does not cause any health problems. In some cases, a parent has the same deletion as the child. Chromosome testing of both parents can provide information about whether the deletion was inherited. Treatment for chromosome 10p deletion is based on the signs and symptoms in each person.
This page is meant to provide general information about 10p deletions. You can contact GARD if you have questions about a specific deletion on chromosome 10p. To learn more about chromosome abnormalities, please visit our GARD webpage on FAQs about Chromosome Disorders.
For more information, visit GARD.