This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD).
Factor V deficiency is an inherited bleeding disorder that prevents blood clots from forming properly. This disorder is caused by mutations in the F5 gene, which leads to a deficiency of a protein called coagulation factor V. The reduced amount of factor V may lead to nosebleeds, easy bruising, and excessive bleeding following surgery or trauma. This condition is inherited in an autosomal recessive manner. Treatment includes fresh blood plasma or fresh frozen plasma infusions during bleeding episodes.
This condition should not be confused with Factor V Leiden thrombophilia, a genetic risk factor for blood clots.
For more information, visit GARD.