Factor V deficiency

Disease Overview

Factor V deficiency is an inherited bleeding disorder that prevents blood clots from forming properly.[286] This disorder is caused by mutations in the F5 gene, which leads to a deficiency of a protein called coagulation factor V.[13329] The reduced amount of factor V may lead to nosebleeds, easy bruising, and excessive bleeding following surgery or trauma.[286][13329] This condition is inherited in an autosomal recessive manner.[287][13329] Treatment includes fresh blood plasma or fresh frozen plasma infusions during bleeding episodes.[286][287] 

This condition should not be confused with Factor V Leiden thrombophilia, a genetic risk factor for blood clots.