Factor XII deficiency

Disease Overview

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. While a lack of factor XII does not cause affected individuals to bleed abnormally, the blood takes longer than normal to clot in a test tube. The condition is usually discovered when prolonged clotting is noticed in the process of running other laboratory tests.[3672] Factor XII deficiency is caused by mutations in the F12 gene. It is inherited in an autosomal recessive manner.[3673] 

Synonyms

• HAF deficiency
• Hageman factor deficiency
• F12 deficiency
• Coagulation factor 12 deficiency
• Factor 12 deficiency