Fibrolamellar carcinoma

Disease Overview

Fibrolamellar carcinoma (FLC) is a rare form of liver cancer which is generally diagnosed in adolescents and young adults (before age 40). Many people with early FLC have no signs or symptoms of the condition. When present, symptoms are often nonspecific (i.e. abdominal pain, weight loss, malaise) and blamed on other, more common conditions. The exact underlying cause of FLC is poorly understood. Unlike other forms of liver cancer, FLC typically occurs in the absence of underlying liver inflammation or scarring; thus, specific risk factors for this condition remain unidentified. FLC is typically treated with surgical resection.[8729][8730][8731]

Synonyms

• Fibrolamellar variant of hepatocellular carcinoma
• Hepatocellular carcinoma (fibrolamellar variant)
• Fibrolamellar hepatocellular carcinoma
• Eosinophilic hepatocellular carcinoma with lamellar fibrosis
• Polygonal cell hepatocellular carcinoma with fibrous stroma
• Hepatocellular carcinoma with increased stromal fibrosis
• Eosinophilic glassy cell hepatoma
• Fibrolamellar oncocytic hepatoma
• FL-HCC
• FHCC
• Fibrolamellar hepatocarcinoma