Focal segmental glomerulosclerosis

Disease Overview

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney.[4099] FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling.[4098][4100] In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).[4100]  The goal of treatment is to control symptoms and prevent chronic kidney failure.[4099] Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.[4099]

Synonyms

• FSGS
• Glomerulosclerosis, focal
• Segmental glomerulosclerosis
• Focal sclerosis with hyalinosis
• Familial idiopathic nephrotic syndrome
• Familial idiopathic steroid-resistant nephrotic syndrome