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Fox-Fordyce disease is a chronic skin disease most common in women aged 13-35 years.[1077] It is characterized by the development of intense itching in the underarm area, the pubic area, and around the nipple of the breast as a result of perspiration which becomes trapped in the sweat gland and surrounding areas.[1078] The cause is unknown, but heat, humidity, and stress may play a role. Treatment may include the use of retinoids, antibiotics, and immunosuppressants.[1077][11973]
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