Iridogoniodysgenesis type 1

Disease Overview

Iridogoniodysgenesis type 1 is a rare condition that affects the eyes. People with this condition are born with malformations of the iris (the colored part of the eye) and cornea, which eventually lead to early-onset glaucoma. The irides of affected people are unusually dark. For example, studies of the condition often describe ‘brown’ irides as a dark, chocolate color and ‘blue’ irides as a very dark, slate gray. The iris also lacks the usual pattern and has a smooth appearance. Iridogoniodysgenesis type 1 is caused by changes (mutations) in the FOXC1 gene and is inherited in an autosomal dominant manner.[11003][11004] Management is based on the signs and symptoms present in each person and is generally focused on the screening and eventual treatment of glaucoma.[11003]

Synonyms

• Iridogoniodysgenesis anomaly, Autosomal dominant
• IRID1
• IGDA
• IGDA syndrome