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Leukonychia totalis is a nail condition characterized by complete whitening of the entire nail plate.[7186] It is usually inherited in an autosomal dominant manner. Less commonly, it may be inherited in an autosomal recessive manner, or acquired (not inherited) during a person’s lifetime.[7189] The inherited forms can be caused by mutations in the PLCD1 gene and generally involve the entire plate of all 20 nails.[7190][7186] In some cases, leukonychia totalis has been associated with various other abnormalities or syndromes. Treatment may focus on the underlying cause when it is associated with another condition.[7186]
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