Minimal change disease

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Disease Overview

Minimal change disease is a kidney disease in which there is damage to the filtering units of the kidney (glomeruli). It is the most common cause of nephrotic syndrome in children.[14256][14257] Nephrotic syndrome is comprised of a group of symptoms including protein in the urine (proteinuria), low protein levels in the blood, high cholesterol and triglycerides, an increased risk for blood clots, and swelling.[1625] Other features of this disease include weight gain and a foamy appearance of the urine.[14257] The cause of minimal change disease is unknown, but it may occur following an allergic reaction or infection.[14256] Treatment may involve the use of steroids.[14256][14257]


Synonyms

  • Idiopathic minimal change nephrotic syndrome
  • Minimal change nephrotic syndrome
  • Minimal change glomerulopathy
  • MCNS

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National Organization for Rare Disorders