Spinocerebellar ataxia 2

Disease Overview

Spinocerebellar ataxia 2 (SCA2) is a progressive disorder that causes symptoms including uncoordinated movement (ataxia), speech and swallowing difficulties, muscle wasting, slow eye movement, and sometimes dementia. Signs and symptoms usually begin in mid-adulthood but can appear any time from childhood to late-adulthood. SCA2 is caused by mutations in the ATXN2 gene and is inherited in an autosomal dominant manner.[1209][7490]

Synonyms

• SCA 2
• Spinocerebellar ataxia type 2
• Spinocerebellar atrophy 2
• Spinocerebellar ataxia Cuban type
• Olivopontocerebellar atrophy 2
• Spinocerebellar ataxia with slow eye movements
• Wadia Swami syndrome
• Spinocerebellar degeneration with slow eye movements
• SDSEM
• Olivopontocerebellar atrophy Holguin type