Tylosis with esophageal cancer

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Disease Overview

Tylosis with esophageal cancer (TOC)is an inherited condition that increases the risk for esophageal cancer. The symptoms of TOC include thickening of the skin on the palms and soles of the feet (palmoplantar keratoderma) and white lesions inside the mouth. People with TOC are at very high risk to develop esophageal cancer. The palmoplantar keratoderma usually occurs in childhood, and esophageal cancer usually occurs in adulthood. TOC is caused by a variant in the RHBDF2 gene and is inherited in an autosomal dominant pattern. Diagnosis is based on the symptoms, clinical exam, and family history. The diagnosis may be confirmed by the results of genetic testing. Treatment is focused on managing the risk for esophageal cancer through screening and avoiding smoking and alcohol use.[5771][15872][15873][15875]


Synonyms

  • Tylosis-oesophageal carcinoma syndrome
  • Howell-Evans syndrome
  • Keratosis palmoplantaris-esophageal carcinoma syndrome
  • Palmoplantar hyperkeratosis-esophageal carcinoma syndrome
  • Tylosis - oesophageal carcinoma
  • Palmoplantar keratoderma-esophageal carcinoma syndrome
  • Bennion-Patterson syndrome
  • TOC
  • Keratosis palmoplantaris with esophageal cancer
  • Howel-Evans syndrome
  • Keratosis palmaris et plantaris with esophageal cancer

For more information, visit GARD.

National Organization for Rare Disorders