Tangier disease

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Disease Overview

Tangier disease (TD) is a rare lipoprotein metabolism disorder characterized biochemically by an almost complete absence of plasma high-density lipoproteins (HDL), and clinically by liver, spleen, lymph node and tonsil enlargement along with peripheral neuropathy in children and adolescents, and, occasionally, cardiovascular disease in adults.


Synonyms

  • A-alphalipoprotein neuropathy
  • ATP-binding cassette transporter A1 deficiency
  • Alpha high density lipoprotein deficiency disease
  • Analphalipo-proteinemia
  • Analphalipoproteinemia
  • HDL lipoprotein deficiency disease
  • HDLDT1
  • Tangier disease
  • cholesterol thesaurismosis
  • defective adenosine triphosphate-binding cassette transporter A1
  • familial Hypoalphalipo-proteinemia
  • familial alpha-lipoprotein deficiency
  • familial high density lipoprotein deficiency
  • familial high density lipoprotein deficiency disease
  • high density lipoprotein deficiency, Tangier type
  • high density lipoprotein deficiency, type 1
  • tgdA-alphalipoprotein neuropathy
  • ATP-binding cassette transporter A1 deficiency
  • Alpha high density lipoprotein deficiency disease
  • Analphalipo-proteinemia
  • Analphalipoproteinemia
  • HDL lipoprotein deficiency disease
  • HDLDT1
  • Tangier disease
  • cholesterol thesaurismosis
  • defective adenosine triphosphate-binding cassette transporter A1
  • familial Hypoalphalipo-proteinemia
  • familial alpha-lipoprotein deficiency
  • familial high density lipoprotein deficiency
  • familial high density lipoprotein deficiency disease
  • high density lipoprotein deficiency, Tangier type
  • high density lipoprotein deficiency, type 1
  • tgd