You are here: Home / Rare Disease Information / Rare Disease Database

Search Rare Diseases

Enter a disease name or synonym to search NORD's database of reports.

0-9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

Severe Combined Immunodeficiency

Abstract

You are reading a NORD Rare Disease Report Abstract. NORD’s full collection of reports on over 1200 rare diseases is available to subscribers (click here for details). We are now also offering two full rare disease reports per day to visitors on our Web site.

Synonyms of Severe Combined Immunodeficiency

  • Bubble Boy Syndrome
  • SCID

Disorder Subdivisions

  • ADA Deficiency
  • Adenosine Deaminase Deficiency
  • Autosomal Recessive Severe Combined Immunodeficiency
  • Bare Lymphocyte Syndrome
  • Reticular Dysgenesis
  • X-Linked Recessive Severe Combined Immunodeficiency with Leukopenia

General Discussion

Severe Combined Immunodeficiency (SCID) is a group of rare congenital syndromes characterized by little if any immune responses. This results in frequent recurring infections. Cellular immune responses involve specialized white blood cells known as T lymphocytes or "killer cells". These cells assist other white blood cells (B lymphocytes) to respond to infectious, foreign agents that invade the body (i.e., bacteria or viruses). The B lymphocytes maintain immunity by enabling the body to produce and preserve circulating antibodies.

People with Severe Combined Immunodeficiency are unusually susceptible to recurrent infections with bacteria, viruses, fungi, and other infectious agents that can be life-threatening.

There are several types of Severe Combined Immunodeficiencies. These include: Autosomal Recessive Severe Combined Immunodeficiency, X-Linked Recessive Severe Combined Immunodeficiency, Adenosine Deaminase Deficiency (ADA), Bare Lymphocyte Syndrome, Severe Combined Immunodeficiency with Leukopenia (Reticular Dysgenesis), and Swiss-type Agammaglobulinemia. Each type of Severe Combined Immune Deficiency is caused by a different genetic defect, but the primary symptom is reduced or absent immune functions, and all types are hereditary.

Organizations related to Severe Combined Immunodeficiency

The information in NORD’s Rare Disease Database is for educational purposes only. It should never be used for diagnostic or treatment purposes. If you have questions regarding a medical condition, always seek the advice of your physician or other qualified health professional. NORD’s reports provide a brief overview of rare diseases. For more specific information, we encourage you to contact your personal physician or the agencies listed as “Resources” on this report.

0-9 - A - B - C - D - E - F - G - H - I - J - K - L - M - N - O - P - Q - R - S - T - U - V - W - X - Y - Z

NORD's Rare Disease Information Database is copyrighted and may not be published without the written consent of NORD.

 
Copyright ©2014 NORD - National Organization for Rare Disorders, Inc. All rights reserved.