CADASIL Eradication Project

CADASIL is the most common form of inherited stroke disorder. It is caused by mutations in the Notch3 gene. By learning how Notch3 mutations lead to CADASIL, we can better understand stroke, dementia, and small vessel diseases, overall. Through precision medicine and the promising potential of gene editing techniques such as CRISPR-Cas9, we will finally be able to start treating this and other once-“incurable” diseases.