Cold Agglutinin Disease Foundation

The Cold Agglutinin Disease E-Support Site is a website created by and for people with cold agglutinin disease (CAD) whose goal is to reach out to others with CAD to offer them an opportunity for support and encouragement. The site helps to alleviate CAD sufferers’ sense of isolation by providing a place to obtain information and talk to each other. Cold agglutinin disease (cold antibody hemolytic anemia) is a rare autoimmune disorder characterized by the premature destruction of red blood cells by the body’s natural defenses against invading organisms (antibodies). Symptoms and findings associated with the disorder may include fatigue; low levels of circulating red blood cells (anemia); persistent yellowing of the skin, mucous membranes, and whites of the eyes (jaundice); and/or sweating and coldness of the fingers and/or toes (digits) and uneven bluish or reddish discoloration of the skin of the digits, ankles, and wrists (acrocyanosis or Raynaud’s sign).