Última actualización:
June 07, 2022
Años publicados: 1986, 1990, 1994, 1995, 2002, 2007
Cockayne Syndrome (CS) is a rare genetic disorder characterized by short stature, an abnormally small head (microcephaly) and neurologic abnormalities that can lead to intellectual disability. Affected children may also have skin that is sensitive to light (photosensitivity); inflammation of peripheral nerves and destruction of the fatty covering (myelin sheath) of nerve fibers; vision abnormalities including cataracts; hearing loss; dental abnormalities and a face with a sunken appearance of the eyes.
The four types of CS have specific characteristics and age of onset. Children with the classical form (CS type I) have growth delay and developmental delays in the first two years of life. Children with CS type II have growth failure noticed at birth and sometimes congenital cataracts and a lack of neurologic development. CS type III presents later in childhood and is generally a milder form of the disease. Children with COFS have severe developmental abnormalities that begin during fetal development and can include stiff joints (contractures) at birth and eyes that don’t fully develop (microphthalmia).
CS type I, the classical form, is characterized by a normal appearing newborn with symptoms that become apparent in the first wo years of life. Vision, hearing and nervous system functioning gets worse over time, resulting in severe disability.
CS type II, the congenital form, is more severe with obvious growth failure at birth and little or no neurological development after birth. Serious vision impairments (cataracts and other structural abnormalities of the eye) are usually present at birth.
CS type III is characterized by essentially normal growth and mental development during the early years, with onset of the typical symptoms of CS later in childhood or teen years. Affected individuals may also have problems with coordination, balance and speech (ataxia) and photosensitivity.
COFS syndrome includes the typical symptoms of CS as well as multiple joint contractures (arthrogryposis) and eye abnormalities.
Brain MRI on children with Cockayne syndrome shows white matter demyelination and cerebellar atrophy.
Children with Cockayne syndrome may have unusual physical features including an abnormally small head (microcephaly), unusually thin nose, “hollow” or sunken appearance to the eyes, large misshapen ears, poor eyelid closure and/or the abnormal forward projection of both the upper and lower jaws (prognathism). There may be an unusual amount of dental decay due to the abnormal placement of the teeth. Affected individuals typically have large hands and feet and unusually long arms and legs in proportion to the size of their body. Joints may also be abnormally large and remain in a fixed position, and the spine may be curved outward when viewed from the side (kyphosis). Other features of Cockayne syndrome may include decreased sweating (hypohidrosis), lack of proper tearing in the eyes and/or thin, dry hair.
Neurological symptoms may include rhythmic, quivering movements (tremors), an unsteady gait (ataxia), and/or the inability to coordinate movement. Affected children may experience varying degrees of intellectual disability, partial loss of hearing, and/or the progressive loss of previously acquired intellectual abilities.
The symptoms of Cockayne syndrome that affect the eyes may include progressive clouding of the lens of the eyes (cataracts), loss of vision because of the wasting of the nerve fibers within the eyes (optic atrophy), degeneration of the retina, and/or the abnormal accumulation of retinal coloration (pigmentation).
Some people with Cockayne syndrome also have an enlarged liver or spleen (hepatosplenomegaly), abnormally high blood pressure (hypertension), premature accumulation of fatty plaques on the walls of the arteries around the heart (arteriosclerotic disease) kidney disease and/or diabetes. Sexual maturation may be delayed.
Cockayne syndrome is caused by changes (pathogenic variants) in the ERCC6 and ERCC8 genes. Pathogenic variants in ERCC6 account for about 65% of cases and pathogenic variants in ERCC8 cause about 35% of cases. These genes are involved in the normal repair of DNA that occurs after damage from ultraviolet light, which is the body’s natural defense against sunburn. Exposure to the ultraviolet component of sunlight damages DNA and because the cells are no longer able to repair the damaged DNA, it accumulates in the cells.
CS is inherited in an autosomal recessive pattern. Recessive genetic disorders occur when an individual inherits a non-working gene from each parent. If an individual receives one working gene and one non-working gene for the disease, the person will be a carrier for the disease, but usually will not show symptoms. The risk for two carrier parents to both pass the non-working gene and, therefore, have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier, like the parents, is 50% with each pregnancy. The chance for a child to receive working genes from both parents is 25%. The risk is the same for males and females.
Cockayne syndrome affects males and females in equal numbers and has been diagnosed in children from many different ethnic backgrounds. The incidence of CS has been estimated to be 2.7 per 1,000,000 births in western Europe, but it is probably underdiagnosed.
Cockayne syndrome is diagnosed by molecular genetic (DNA) testing for pathogenic variants in the ERCC6 or ERCC8 genes. If pathogenic variants in these genes are not found, a DNA repair assay on skin cells can be done to look for sensitivity to ultraviolet radiation.
Treatment
Treatment of Cockayne syndrome is symptomatic and supportive. A supportive team approach can benefit for children with CS and may include special education, physical therapy, and other medical, social, and/or vocational services. Genetic counseling is recommended for family members.
Information on current clinical trials is posted on the Internet at https://clinicaltrials.gov/ All studies receiving U.S. Government funding, and some supported by private industry, are posted on this government web site.
For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:
Tollfree: (800) 411-1222
TTY: (866) 411-1010
Email: [email protected]
Some current clinical trials also are posted on the following page on the NORD website: https://rarediseases.org/living-with-a-rare-disease/find-clinical-trials/
For information about clinical trials sponsored by private sources, contact: https://www.centerwatch.com/
For information about clinical trials conducted in Europe, contact: https://www.clinicaltrialsregister.eu
INTERNET
Cockayne syndrome. Genetic and Rare Diseases Information Center (GARD). Last Updated: Nov. 8, 2021. https://rarediseases.info.nih.gov/diseases/6122/cockayne-syndrome Accessed June 2, 2022.
Laugel V. Cockayne Syndrome. 2000 Dec 28 [Updated 2019 Aug 29]. In: Adam MP, Mirzaa GM, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2022. Available from: https://www.ncbi.nlm.nih.gov/books/NBK1342/ Accessed June 2, 2022.
Imaeda S. Cockayne Syndrome Medscape. Updated Jun 25, 2018. https://emedicine.medscape.com/article/1115866-overview Accessed June 2, 2022.
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Aprende más https://rarediseases.org/patient-assistance-programs/caregiver-respite/The information provided on this page is for informational purposes only. The National Organization for Rare Disorders (NORD) does not endorse the information presented. The content has been gathered in partnership with the MONDO Disease Ontology. Please consult with a healthcare professional for medical advice and treatment.
The Genetic and Rare Diseases Information Center (GARD) has information and resources for patients, caregivers, and families that may be helpful before and after diagnosis of this condition. GARD is a program of the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH).
View reportOrphanet has a summary about this condition that may include information on the diagnosis, care, and treatment as well as other resources. Some of the information and resources are available in languages other than English. The summary may include medical terms, so we encourage you to share and discuss this information with your doctor. Orphanet is the French National Institute for Health and Medical Research and the Health Programme of the European Union.
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