Laurence-Moon Syndrome

Disease Overview

Summary

Laurence-Moon syndrome (LNMS) is a genetic condition that results in a complex association of problems that affect several different body parts. People with LNMS may have difficulties with functions of the brain, eyes, ears, stomach, kidneys, hands and feet. They often also demonstrate a tendency to short stature and obesity. Because of the many complications seen in this condition, it is important that the patient has a strong, comprehensive health care team.

Introduction

LNMS was later termed Laurence-Moon-Bardet-Biedl syndrome because of similarities with Bardet-Biedl syndrome (BBS). It is often considered, but still debated, whether BBS is a distinct condition. Arguments are based on differences in the underlying genetic causes of these the disorders (see Related Disorders). These two disorders also share similarity to Oliver-McFarlane syndrome (OMS). All three conditions are characterized by progressive blindness, obesity, and learning disabilities.

Differences in the clinical presentation include subtle but important hints as offered in the following examples. LNMS is associated with difficulty in controlling body movements, which is also seen in adolescent and adult patients with OMS and less frequently in BBS. LNMS and OMS are associated with abnormal pituitary gland function. BBS is associated with extra fingers and toes, and kidney and liver dysfunction. OMS is associated with abnormal growth of eyelashes and eyebrows. Neither LNMS nor BBS are generally associated with such difficulty.

Of important note to patients and physicians, the practical management of these conditions is similar. These conditions are all managed with close attention to each individual patient’s symptoms. This contributes to the ability to group LNMS, BBS, and OMS together in clinical settings. For the purposes of the description of these entities by what is known of their genetic cause, we have drawn stricter differentiating lines between them and offer distinct articles on each related disorder.

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Synonyms

• adipogenital-retinitis pigmentosa syndrome
• LNMS
• LMS

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Signs & Symptoms

The major signs that people present with which raise the suspicion that they may have LNMS are summarized below. The individual components of this condition can notably vary greatly in severity however.

Physicians may begin to investigate the diagnosis of a genetic condition when they identify structural abnormalities of the hands and feet. Abnormalities commonly include both too many and too few fingers or toes. Between LMS and BBS, it is the people with BBS that are born with an extra digit near the pinky or an extra toe near the fifth “little” toe. In medical terminology, this is described as a ‘postaxial polydactyly’. Interestingly, the presence of an extra toe is more common than that of an extra finger. In patients with LNMS, fingers and toes may however have some degree of webbing, which is referred to as “syndactyly”. Syndactyly is especially common between the second and third toes. Less often, fingers and toes may be abnormally short in length. This finding is called a “brachydactyly” and can be especially expected to affect the thumb. The thumb may additionally be placed subtly closer to the wrist than expected. Finally, the feet may also be overall short in length, of wide width, and carry a flat arch.

In regard to additional skeletal changes, patients with LNMS may notice or be told that they have some slight changes in the basic shape of their teeth. Teeth are made up of two major segments, the body and roots. Patients with LNMS may experience taurodontism, in which the development of tooth’s body is enlarged relative to the roots. Most commonly, it is the flat, molar teeth at the back of the mouth that are affected. Most commonly, this condition is noted at the time of first dental x-rays, where the teeth will appear more rectangular than expected.

People with LNMS are also often burdened by problems with the coordination of their body’s movements. Many patients report a significant degree of clumsiness and often walk with legs in a wide-based stance. Walking heel-to-toe may be difficult. Such impairment is specifically the result of problems with the cerebellum, the sub-section of the brain responsible for coordination. The dysfunction of the cerebellum can lead to dysfunction of the spinal nerve conduction pathways that communicate signals between the brain and muscles. This results in a complex constellation of movement irregularities. The term ataxia is used to describe this loss of control over coordinated bodily movements, and can make it difficult to speak, eat, walk, and maintain balance. Ataxia is accompanied by spasticity, a continuous contraction of muscles in an involuntary manner. The term contracture is used to describe a hardening and shortening of muscles and surrounding connective tissue.

People with LNMS also often experience other problems related to functions controlled by the brain.

Most patients with LNMS will experience a gradual loss of vision. The term “retinitis pigmentosa” is used to describe the particular, gradual-onset, vision loss that progresses according to a particular pattern. Retinitis pigmentosa begins with a night blindness that worsens with a loss of the ability to distinguish colors from one another, finally deteriorating into “tunnel vision”. (For more information, choose “Retinitis Pigmentosa” as your search term in the Rare Disease Database).

Mild-to-moderate learning difficulties are common in individuals with LNMS. Often, learning disabilities are attributed to weakened cognitive capacity. Some individuals affected with LNMS may have true learning disabilities due to dysfunction of brain development. However, it is important to be sure that suspected disabilities (such as delayed speech or reading skills) are not due to underlying visual impairment. If the learning disability is rooted in neurological impairments, they are often associated with symptoms of poor coordination, gross and fine motor skills, and social milestones in childhood such as inability to play complicated games with other children.

People living with LNMS have been found to have smaller than average size anterior pituitary glands and can suffer from a series of different complications as a result. The anterior portion of the pituitary gland is responsible for regulating many functions including the body’s metabolism, emotional responses to stressors, physical bodily growth, and reproductive capacity. The body’s metabolism is controlled by thyroid stimulating hormone. With low levels of thyroid stimulating hormone, people will experience many different symptoms: fatigue, sensitivity to cold, poor ability to concentrate, weight gain, constipation, shortness of breath. The body will potentially change its common behaviors. For example, skin will become dry and course, hair will fall out, reflexes will slow.

People with LNMS often have decreased levels of the sex hormones estrogen and testosterone. This is also due to the small size of the pituitary gland, a small gland located in the brain that is responsible for producing the chemical signals that orchestrate the production of sex hormones. As a result of a weak signal to produce estrogen and testosterone, the reproductive organs of both men and women living with LNMS may be underdeveloped, resulting in reduced fertility or even infertility. Males with LNMS may have an underdeveloped set of testicles that may be undescended. In females, the uterus, fallopian tubes, and ovaries are often underdeveloped. Menstruation cycles can be delayed from the average first age of onset and when they do begin, may follow an irregular cycle.

Other less common features that have been reported in patients living with LNMS include a skull shape shorter than average, termed “brachycephaly” and electrical abnormalities of the heart. (For more information, choose “congenital heart block” as your search term in the Rare Disease Database). People may also experience a loss of hearing, increased incidence of diabetes, liver fibrosis, and urinary and genital structural malformations.

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Causes

LNMS is most commonly attributed to changes (mutations) in the PNPLA6 gene. Genes are specific sequences in DNA that provide instructions for the production of proteins. Proteins serve as the body’s cellular machinery and building blocks. The PNPLA6 gene is responsible for the production of proteins that drive the breakdown of cell membranes. The PNPLA6 protein is an enzyme that is thought to drive the growth of nerve and non-nerve cells as they grow and mature. This gene is notably associated not only with LNMS but also Boucher-Neuhauser syndrome, Gordon-Holmes syndrome, and spastic paraplegia type 39. These conditions are described in brief under the Related Disorders section.

LNMS follows an autosomal recessive pattern of inheritance. Recessive genetic disorders occur when an individual inherits two copies of an abnormal gene for the same trait, one from each parent. If an individual inherits one normal gene and one gene for the disease, the person will be a carrier for the disease but usually will not show symptoms. The risk for two carrier parents to both pass the altered gene and have an affected child is 25% with each pregnancy. The risk to have a child who is a carrier like the parents is 50% with each pregnancy. The chance for a child to receive normal genes from both parents is 25%. The risk is the same for males and females.

Parents who are close relatives (consanguineous) have a higher chance than unrelated parents to both carry the same abnormal gene, which increases the risk to have children with a recessive genetic disorder.

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Affected populations

Males and females are affected equally. In North America, it is estimated that 1 in 100,000 people is affected by LNMS. Kuwait and Newfoundland are two places where the number of people affects with LNMS are comparatively high.

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Disorders with Similar Symptoms

The following conditions have notably been considered in the differential diagnosis for patients with LNMS given the similar presentation of symptoms. They are only briefly summarized here. Without genetic testing, it can be very difficult to clinically differentiate these conditions.

Bardet-Biedl Syndrome (BBS)
BBS is characterized by central obesity, intellectual impairment with kidney anomalies, polydactyly, retinal degeneration and hypogenitalism. This condition is associated with a series of different mutations, especially in proteins involved in the assembly of the BBSome. The BBSome is an eight-protein complex that serves in the assembly of cilia, slender lashes that extend from cell bodies. Cilia serve various functions from helping the cell move to monitoring chemicals in its environment. (For more information, choose “Bardet-Biedl Syndrome” as your search term in the Rare Disease Database).

Boucher-Neuhauser Syndrome (BNS)
BNS is a condition that results in ataxic movement abnormalities and a hypogonadotropic hypogonadism (poor sexual development resulting from poor pituitary gland function). People with BNS often also have chorioretinal degeneration, resulting in vision loss. They may sometimes demonstrate developmental delays or rapid side-to-side movement of the eyes called nystagmus. This condition has been associated with mutations in the PNPLA6 gene and with another gene called RNF216. RNF216 is responsible for the tagging of cell proteins destined for degradation.

Gordon-Holmes Syndrome (GHS)
GHS describes the association of ataxic movement abnormalities with hypogonadotropic hypogonadism as describes above. As adults, people with GHS demonstrate neurodegenerative changes. A subset of patients with GHS may demonstrate exaggerated, brisk reflexes. This condition is associated with mutations in the PNPLA6 gene.

Joubert Syndrome
Joubert syndrome is a severe disorder in which children do not live beyond three-years of age. People born with this condition experience ataxic and flaccid movement difficulties, abnormalities in the movements of the eyes, mouth and difficulty breathing. They experience retinal dystrophy, developmental delays and multiple visceral organ problems. They have characteristic body features that include broad foreheads, arched eyebrows, ptosis, hypertelorism, low-set ears, and a triangular mouth. (For more information on this condition, search for “Joubert” in the Rare Disease Database.)

McKusick-Kaufman Syndrome (MSK)
MSK is a condition associated with polydactyly, heart, genital and urinary anatomy abnormalities. Female patients may have an absent vaginal with mucoid accumulations identifiable within an intact uterus within the abdomen. They may alternatively have a double vaginal or uterine structures. Males may have undescended testicles, abnormal opening of the urethra over the penile head. Either sex may have fibrosis or degeneration of their ureters, the conduit for urine formed by the kidneys destined for storage in the bladder.

Meckel Syndrome
Meckel Syndrome is another ciliopathy like BBS. It however describes the association of retinal degeneration, polydactyly, and renal cysts, poor development of the brain and liver as well as poor lung function resulting from low amniotic fluid volumes within the placenta during the pregnancy. (For more information on this condition, search for “Meckel” in the Rare Disease Database.)

Oliver-McFarlane Syndrome (OMS)
OMS describes an association of trichomegaly, chorioretinal dystrophy, intellectual disability, and hypopituitarism. Patients often have associated physical features including a large frontal skull, prominent chin, mid-front scalp hair loss, bushy eyebrows, and long eyelashes. This condition is associated with mutations in the PNPLA6 gene.

Spastic Paraplegia Type 39 (SPG39)
SPG39 describes the association of upper motor neuron involvement and/or cerebellar ataxia, peripheral neuropathy, and/or reduced cognitive capacity. This condition is associated with mutations in the PNPLA6 gene.

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Diagnosis

Due to its highly variable clinical presentation of the condition, no formal diagnostic criteria have been established for LMS or, for that matter, any PNPLA6-related disorders. LMS is definitively diagnosed with molecular testing for mutations in the PNPLA6 gene.

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Standard Therapies

Treatment
The treatments available for LNMS are oriented towards managing the manifestations of the illness.

People with LNMS often experience ataxia, spasticity, and contracture that compromise their ability to move comfortably. Physical therapy aimed towards improving strength and agility is key. Often walking can be assisted by tools such as ankle-foot orthotic braces, weight-bearing walkers, etc. Physical exercise can reduce the symptoms of ataxia, spasticity, and prevent contracture. A dedicated regimen of nutritious, well-balanced meals and regular exercise is recommended to avoid some of the less common but equally severe aspects that have been noted to affect patients with LNMS. There is most notably, an increased incidence of diabetes and abnormal cholesterol levels in patients with LNMS.

The poor functional capacity of the anterior pituitary gland that results in slowed metabolism, poor growth, and impaired fertility can be managed with hormone replacement therapies. Levothyroxine is a medication that mimics the functions of the thyroid hormone and can aid in speeding up the metabolism of the body, resulting in reduced symptoms of lethargy, hair loss, and obesity. Growth hormone supplementation can be offered to reduce the burden of short stature in patients identified as children.

It is important for patients with LNMS to be under the care of an ophthalmologist. There is no cure for the vision problems that accompanies LNMS, but ophthalmologists can help create corrective lenses against developing problems. Individuals with LNMS should undergo regular ophthalmologic examinations and keep up with their changing prescriptions. Since visual impairment is a major hurdle to learning in the classroom, special services might be organized on an individual basis between a child’s physician and their school.

For patients living with LNMS, it is important to recognize that the many difficulties described above are associated with the brain’s neurological function. It is thus important to protect baseline function capacity of the brain. Inactivity and obesity exacerbate neuropathy. Alcohol and recreational drugs should be avoided.

Generally, very little information exists to guide women living with rare diseases who are interested in becoming pregnant. Pregnancy is well known to take many physical demands on a woman’s body and women who are living with LNMS are generally warned that symptoms of ataxia may worsen or even develop for the first time during pregnancy. Pregnant women with LNMS should be followed closely by obstetricians that are well trained in dealing with high-risk pregnancies.

Patients living with LNMS experience alterations to the shape of their teeth. Taurodontism is generally noted at the dental office at the time of first x-rays. Extra care may be needed in brushing and cleaning all aspects of the affected teeth, and dentists may need special tools to examine all aspects of the affected teeth.

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Clinical Trials and Studies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site. This site provides summaries and investigator contact information on both actively enrolling and completed clinical trials, with results where available.

New open trials and trial results are constantly being updated. Patients are encouraged to check postings regularly.

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov . All studies receiving U.S. government funding, and some supported by private industry, are posted on this government web site.

For information about clinical trials being conducted at the NIH Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Toll-free: (800) 411-1222
TTY: (866) 411-1010
Email: [email protected]

Some current clinical trials also are posted on the following page on the NORD website:
https://rarediseases.org/living-with-a-rare-disease/find-clinical-trials/

For information about clinical trials sponsored by private sources, in the main, contact:
www.centerwatch.com

For more information about clinical trials conducted in Europe, contact:
https://www.clinicaltrialsregister.eu/

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References

JOURNAL ARTICLES
Hufnagel RB, Arno G, Hein ND, et al. Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes. J Med Genet. 2015 Feb;52(2):85-94.

Andersson EM, Axelsson S, Gjølstad LF, Storhaug K. Taurodontism: A minor diagnostic criterion in Laurence-Moon/Bardet-Biedl syndromes. Acta Odontol Scand. 2013 Nov;71(6):1671-4.

Habek D, Franicevic D, Stanojevic M. Recurrent pyocolpos in a Laurence-Moon-Bardet-Biedl syndrome. J Pediatr Adolesc Gynecol. 2008 Feb;21(1):31-2.

Beales P, Elcioglu N, Woolf A, Parker D, Flinter F.New criteria for improved diagnosis of Bardet-Biedl syndrome: results of a population survey. J. Med. Genet. 1999; 36(6):437–46.

Laurence JZ, Moon RC. Four cases of “retinitis pigmentosa” occurring in the same family, and accompanied by general imperfections of development. Obes Res. 1995 Jul;3(4):400-3.

Chalvon-Demersay, A, Tardieu, M, Crosnier, H, Benichou, J J, Pienkowski, C, Rochiccioli, P, Labrune, B Syndrome de Laurence-Moon (Bardet-Biedl) avec deficit en hormone de croissance. Arch Franc. Pediat. 1993;50:859-862.

Farag, T I, Teebi, AS. Bardet-Biedl and Laurence-Moon syndromes in a mixed Arab population. Clin. Genet.1988;33:78-82.

INTERNET
Laurence-Moon Syndrome. Genetic and Rare Diseases Information Center. Last updated: 6/18/2015.
https://rarediseases.info.nih.gov/diseases/12635/laurence-moon-syndrome . Accessed May 25, 2018.

Laurence-Moon Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 08/10/2017.
https://www.omim.org/entry/245800. Accessed May 25, 2018.

Bardet-Biedl Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 08/10/2017.
https://www.omim.org/entry/209900. Accessed May 25, 2018.

Boucher-Neuhauser Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 02/09/15. https://www.omim.org/entry/215470. Accessed May 25, 2018.

Gordon-Holmes Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 02/09/15. https://www.omim.org/entry/212840. Accessed May 25, 2018.

Joubert Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 02/09/15. https://www.omim.org/entry/213300. Accessed May 25, 2018.

McKusick-Kaufman Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 02/09/15. https://www.omim.org/entry/236700. Accessed May 25, 2018.

Oliver-McFarlane Syndrome. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 02/09/15. https://www.omim.org/entry/275400. Accessed May 25, 2018.

Spastic Paraplegia 3. Online Mendelian Inheritance in Man: An Online Catalog of Human Genes and Genetic Disorders. 02/09/15. https://www.omim.org/entry/182600. Accessed May 25, 2018.

Synofzik M, Hufnagel RB, Züchner S. PNPLA6-Related Disorders. 2014 Oct 9 [Updated 2015 Jun 11]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from: https://www.ncbi.nlm.nih.gov/books/NBK247161/ Accessed June 21, 2018.

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Programs & Resources

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More Information

The information provided on this page is for informational purposes only. The National Organization for Rare Disorders (NORD) does not endorse the information presented. The content has been gathered in partnership with the MONDO Disease Ontology. Please consult with a healthcare professional for medical advice and treatment.

GARD Disease Summary

The Genetic and Rare Diseases Information Center (GARD) has information and resources for patients, caregivers, and families that may be helpful before and after diagnosis of this condition. GARD is a program of the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH).

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Orphanet

Orphanet has a summary about this condition that may include information on the diagnosis, care, and treatment as well as other resources. Some of the information and resources are available in languages other than English. The summary may include medical terms, so we encourage you to share and discuss this information with your doctor. Orphanet is the French National Institute for Health and Medical Research and the Health Programme of the European Union.

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OMIM

Online Mendelian Inheritance In Man (OMIM) has a summary of published research about this condition and includes references from the medical literature. The summary contains medical and scientific terms, so we encourage you to share and discuss this information with your doctor. OMIM is authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine.

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