• Disease Overview
  • Synonyms
  • Signs & Symptoms
  • Causes
  • Affected Populations
  • Disorders with Similar Symptoms
  • Diagnosis
  • Standard Therapies
  • Clinical Trials and Studies
  • References
  • Programs & Resources
  • Complete Report

Papillitis

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Last updated: March 30, 2008
Years published: 1989, 1994, 1997, 2005


Disease Overview

Papillitis, also known as optic neuritis, is characterized by inflammation and deterioration of the portion of the optic nerve known as the optic disk. Also referred to as the “blind spot,” the optic disk (optic papilla) is that portion of the optic nerve that enters the eye and joins with the nerve-rich membrane lining the eye (retina). The optic nerves are the pair of nerves (second cranial nerves) that transmit impulses from the retina to the brain. Individuals with papillitis experience loss of vision in one eye that may occur within several hours of onset. The severity of visual impairment may vary from case to case, ranging from slight visual deficiency to complete loss of light perception. In addition, affected individuals experience a reduction in color perception. In some cases, spontaneous recovery may occur. However, in other cases, permanent visual impairment may result if the underlying cause is not detected or treated. Papillitis may occur for unknown reasons, after a viral illness, or due to or in association with a number of different underlying disorders or other factors.

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Synonyms

  • Optic Nerve Papillitis
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Signs & Symptoms

The symptoms of papillitis include loss of vision, pain in the eye, and interference with accurate color vision (dyschromatopsia).

Individuals with papillitis usually experience unilateral loss of vision. That is, they lose sight in one eye (about 70% of cases), usually within a short time (a few hours) of having become aware of diminished sight. This condition is usually rapidly progressive.

The intensity of vision impairment varies from case to case, ranging from slight visual deficiency to complete loss of light perception. In addition, affected individuals experience a reduction in color perception. In some cases, spontaneous recovery may occur. However, in other cases, permanent visual impairment may result if the underlying cause is not detected or treated. Papillitis may occur for unknown reasons, after a viral illness, or due to or in association with a number of different underlying disorders or other factors.

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Causes

There are many possible causes of papillitis. These include diseases that result in damage to the lining of nerves (demyelinating diseases) such as multiple sclerosis and encephalomyelitis; viral or bacterial infections such as polio, measles, pneumonia, or meningitis; nutritional or metabolic disorders such as diabetes, pernicious anemia, and hyperthyroidism; secondary complications of other diseases; reactions to toxic substances such as methanol, quinine, salicylates, and arsenic; and trauma.

In patients over 60 years of age, a common cause of papillitis is temporal arteritis (giant cell arteritis). In such cases, papillitis can spread to the other eye resulting in bilateral blindness.

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Affected populations

Papillitis affects males and females in equal numbers and can occur at any age. A percentage of people with papillitis may eventually be diagnosed with multiple sclerosis. (for more information on this disorder, see the Related Disorders section of this report.)

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Diagnosis

Diagnostic testing may include testing for visual acuity, testing for color vision, examination of the optic disc by means of ophthalmoscopy and magnetic resonance imaging.

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Standard Therapies

Treatment

If spontaneous remission does not occur in people with papillitis it is usually treated with the corticosteroid drugs prednisone or methylprednisolone. Other treatment is symptomatic and supportive.

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Clinical Trials and Studies

Information on current clinical trials is posted on the Internet at www.clinicaltrials.gov. All studies receiving U.S. government funding, and some supported by private industry, are posted on this government website.

For information about clinical trials being conducted at the National Institutes of Health (NIH) Clinical Center in Bethesda, MD, contact the NIH Patient Recruitment Office:

Tollfree: (800) 411-1222

TTY: (866) 411-1010

Email: prpl@cc.nih.gov

For information about clinical trials sponsored by private sources, contact:

www.centerwatch.com

MidAmerica Neuroscience Institute is currently recruiting patients experiencing a first “demyelinating event” for a clinical trial. For information, go to www.clinicaltrial.gov or contact:

Laurie A. Dressman, RN, BA at 816-753-8800 ext 124, at

MidAmerica Neuroscience Institute

Kansas City, MO 64108

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References

TEXTBOOKS

Beers MH, Berkow R., eds. The Merck Manual, 17th ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999:739.

Bennett JC, Plum F., eds. Cecil Textbook of Medicine. 20th ed. W.B. Saunders Co., Philadelphia, PA; 1996:2016-17.

Stein JH, Hutton JJ, Kohler PO, et al., eds. Internal Medicine. 4th ed. Mosby-Yearbook, Inc., St. Louis, MO. 1994:1152-53.

Kanski JJ., ed. Clinical Ophthalmology. 4th ed. Butterworth-Heinemann. Oxford, UK; 1999:590-93.

Newell FW., ed. Ophthalmology: Principles and Concepts. 7th ed. Mosby Year Book, St. Louis, MO; 1991:348-49.

REVIEW ARTICLES

Myers TD, Smith JR, Wertheim MS, et al. Use of corticoid sparing systemic immunosuppression for treatment of corticoid dependent optic neuritis not associated with demyelinating disease. Br J Ophthalmol. 2004;17:3-8.

Margalit E, Sadda SR. Retinal and optic nerve diseases. Artif Organs. 2003;27:963-74.

Parisi V. Correlations between morphological and functional retinal impairment in patients affected by ocular hypertension, glaucoma, demyelinating optic neuritis and Alzheimer’s disease. Semin Ophthalmol. 2003;18:50-57.

Kesler A, Pianka P. Toxic optic neuropathy. Curr Neurol Neurosci Rep. 2003;3:410-14.

Chan JW. Optic neuritis in multiple sclerosis. Ocul Immunol Inflamm. 2002;10:161-86.

JOURNAL ARTICLES

Pirko I, Blauwet LK, Lesnick TJ, et al. The natural history of recurrent optic neuritis. Arch Neurol. 2004;61:1401-05

[No authors listed]. Neurologic Impairment 10 Years after Optic Neuritis. Arch Neurol. 2004;61:1386-89.

Hickman SJ, Toosy AT, Miszkiel KA, et al. Visual recovery following acute optic neuritis: A clinical, electrophysiological and magnetic resonance imaging study. J Neurol. 2004;251:996-1005.

Lim ET, Grant D, Pashenkov M, et al. Cerebrospinal fluid levels of brain specific proteins in optic neuritis. Mult Scler. 2004;10:261-65.

Craenen G, Brown SM, Freedman KA, et al. Rapid, painless unilateral vision loss in a 37-year-old healthy woman. Surv Ophthalmol. 2004;49:343-48.

Beck RW, Gal RL, Bhatti MT, et al. Visual function more than 10years after optic neuritis: experience of the optic neuritis treatment trial. Am J Ophthalmol. 2004;137:77-83. Errata in: Am J Ophthalmol. 2004;137:following 793. Am J Ophthalmol. 2004;138:following 321.

Fazzone HE, Lefton DR, Kupersmith MJ. Optic neuritis: Correlation of pain and magnetic resonance imaging. Ophthalmology. 2003;110:1646-49.

FROM THE INTERNET

Swallow C. Optic Neuritis. emedicine. Last Updated: July 20, 2004. 9pp.

www.emedicine.com/radio/topic488.htm

Giovannini J, Chrousos G. Pseudopapilledema. emedicine. Last Updated: August 26, 2002. 6pp.

www.emedicine.com/oph/topic615.htm

Papillitis. The Merck Manual. 2004. 2pp.

www.merck.com/mrkshared/mmanual/section8/chapter101/101b.jsp

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Programs & Resources

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Additional Assistance Programs

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NORD and MedicAlert Foundation have teamed up on a new program to provide protection to rare disease patients in emergency situations.

Learn more https://rarediseases.org/patient-assistance-programs/medicalert-assistance-program/

Rare Disease Educational Support Program

Ensuring that patients and caregivers are armed with the tools they need to live their best lives while managing their rare condition is a vital part of NORD’s mission.

Learn more https://rarediseases.org/patient-assistance-programs/rare-disease-educational-support/

Rare Caregiver Respite Program

This first-of-its-kind assistance program is designed for caregivers of a child or adult diagnosed with a rare disorder.

Learn more https://rarediseases.org/patient-assistance-programs/caregiver-respite/

Patient Organizations


National Organization for Rare Disorders