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PO Box 404
Stony Brook, NY 11790 USA
The APS Type 1 Foundation is an internet resource of information on autoimmune polyglandular syndrome type 1 (APS type 1/APECED). Its main goal is education, awareness, fund raising, and patient unification. APECED is a very rare genetic syndrome involving the autoimmune system. It is a combination of several distinct disorders and is defined as the subnormal functioning of several endocrine glands at the same time (concurrently). The acronym APECED stands for autoimmune polyendocrinopathy (APE), candidiasis (C) and ectodermal dysplasia (ED). Autoimmune disease affecting one gland is frequently followed by the impairment of other glands. Beginning in childhood, yeast infections of either the mouth or nails are usually one of the first apparent symptoms of APECED. Low plasma levels of calcium and phosphate (hypoparathyroidism) are often diagnosed before adrenal dystrophy. There may be an inability to adequately absorb nutrients with resulting diarrhea. Anemia, autoimmune thyroid disease, and loss or delay of sexual development may also occur. The combination of ectodermal dysplasia with candidiasis or hypoparathyroidism may also indicate an APECED patient.
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