The Association for X and Y Variations (AXYS) is an advocacy, education and support organization for individuals with X and Y chromosome variations and their families. AXYS, formerly known as Klinefelter Syndrome and Associates (KS&A), was founded in 1989 by Melissa Aylstock, the mother of a child with Klinefelter syndrome. Her goal was to provide support for other families, raise awareness among the public, and promote education and research. Over time, KS&A expanded its focus to include other SCA conditions. The name was changed to AXYS in 2014 to reflect all X and Y chromosome variations. The mission of AXYS is to help individuals with one or more extra X and/or Y chromosomes and their families to lead fuller, more productive lives.