Greig Cephalopolysyndactyly Syndrome
NORD gratefully acknowledges Elaine Lee, NORD Editorial Intern from the University of Notre Dame, and Leslie G. Biesecker, MD, Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, for assistance in the preparation of this report.
Synonyms of Greig Cephalopolysyndactyly Syndrome
- Frontodigital Syndrome (obsolete)
- Hootnick-Holmes Syndrome (obsolete)
- Polysyndactyly-Dysmorphic Craniofacies, Greig Type
- Cephalopolysyndactyly Syndrome
- Greig Syndrome
Greig cephalopolysyndactyly syndrome (GCPS) is a rare genetic disorder characterized by physical abnormalities affecting the fingers and toes (digits) and the head and facial (craniofacial) area. Characteristic digital features may include extra (supernumerary) fingers and/or toes (polydactyly), webbing and/or fusion of the fingers and/or toes (cutaneous or osseous syndactyly), and/or additional abnormalities. Craniofacial malformations associated with this disorder may include a large and/or unusually shaped skull; a high, prominent forehead (frontal bossing); an abnormally broad nasal bridge; widely spaced eyes (ocular hypertelorism); and/or other physical abnormalities. The range and severity of symptoms may vary greatly among affected individuals. In most cases, GCPS is inherited as an autosomal dominant trait.
(Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder [e.g., digital abnormalities, craniofacial abnormalities, etc.].)
NORD Member Organizations
1989, 1996, 1999, 2005, 2015
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