NORD gratefully acknowledges Nicholas J. Talley, MD, PhD, Professsor and pro Vice-Chancellor, University of Newcastle, Adjunct Professor of Medicine, Mayo Clinic and John Y. Kao, MD, Director, Michigan Gut Peptide Center Visiting Professor Series, Assistant Director of GI Fellowship Program, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, Michigan, for assistance in the preparation of this report.
Menetrier disease is a rare disorder characterized by massive overgrowth of mucous cells (foveola) in the mucous membrane lining the stomach, resulting in large gastric folds. The main symptom associated with Menetrier disease is pain in the upper middle region of the stomach (epigastric pain). The cause of Menetrier disease is unknown.
There is considerable confusion and contradiction in the medical literature regarding disorders involving large gastric folds. The name Menetrier disease is often erroneously used to describe any condition with large gastric folds or as a synonym for giant hypertrophic gastritis (GHG). However, Menetrier disease is not a true form of gastritis. A diagnosis of Menetrier disease should be reserved for individuals with large gastric folds due to overgrowth of mucous cells. There is minimal or no stomach inflammation in Menetrier disease. Because inflammation is minimal or not present, Menetrier disease is classified as a form of hyperplastic gastropathy and not as a form of gastritis. Some researchers believe that Menetrier disease and GHG may be variants of the same disorder or different parts of one disease spectrum.
Please note that some of these organizations may provide information concerning certain conditions potentially associated with this disorder.
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