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tropical spastic paraparesis

The information provided on this page is for informational purposes only. The National Organization for Rare Disorders (NORD) does not endorse the information presented. The content has been gathered in partnership with the MONDO Disease Ontology. Please consult with a healthcare professional for medical advice and treatment.

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Disease Overview

Tropical spastic paraparesis is a chronic systemic immune-mediated inflammatory myeloneuropathy, more frequently reported in women than in men, that usually presents in adulthood with slowly progressive spastic paraparesis of the lower limbs, bladder and bowel dysfunction, and sensory disturbances in the lower extremities (e.g. paresthesia and dysesthesia) and that is associated with a human T-cell lymphotropic virus type 1 (HTLV-1) infection.

Synonyms

  • HAM/TSP
  • HTLV-1 associated myelopathy/tropical spastic paraparesis
  • HTLV-1-associated myelopathy/tropical spastic paraparesis
  • HTLV-associated myelopathy
  • Human T-cell leukaemia virus type 1 associated myelopathy/tropical spastic paraparesis
  • Human T-cell leukemia virus type 1 associated myelopathy/tropical spastic paraparesis
  • Human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis
  • Human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis
  • TSP
  • familial spastic paraparesis, HTLV-1-associated
  • ham
  • ham/TSP
  • myelopathy, HTLV-1-associated
  • tropical spastic paralysis
  • tropical spastic paraparesis (formerly)
  • tropical spastic paraplegia
GARD Disease Summary

The Genetic and Rare Diseases Information Center (GARD) has information and resources for patients, caregivers, and families that may be helpful before and after diagnosis of this condition. GARD is a program of the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH).

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Orphanet

Orphanet has a summary about this condition that may include information on the diagnosis, care, and treatment as well as other resources. Some of the information and resources are available in languages other than English. The summary may include medical terms, so we encourage you to share and discuss this information with your doctor. Orphanet is the French National Institute for Health and Medical Research and the Health Programme of the European Union.

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OMIM

Online Mendelian Inheritance In Man (OMIM) has a summary of published research about this condition and includes references from the medical literature. The summary contains medical and scientific terms, so we encourage you to share and discuss this information with your doctor. OMIM is authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine.

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