Adermatoglyphia

Disease Overview

Adermatoglyphia is a rare condition that is characterized by the lack of ridges on the skin of the fingers, toes, palms of the hand and soles of the feet. Because the pattern of these ridges form each person’s unique fingerprints, people with this condition are not able to be identified by their fingerprints. In some cases, adermatoglyphia may occur without any additional signs or symptoms; however, it may be associated with other skin abnormalities including small white bumps on the face, blistering of the skin, and/or a reduced number of sweat glands on the hands and feet. Adermatoglyphia is caused by changes (mutations) in the SMARCAD1 gene and is inherited in an autosomal dominant manner. Treatment is typically only necessary if other features are present.[8821][8822]

Synonyms

• Absence of fingerprints
• ADERM
• ADG
• Immigration delay disease
• Congenital absence of fingerprints
• Isolated congenital adermatoglyphia