This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD).
Adult-onset Still’s disease (AOSD) is an inflammatory condition that affects multiple organs. The most common symptoms are high fevers, skin rash, arthritis, and high levels of ferritin, a protein that stores iron in the blood. Other symptoms include an enlarged spleen and lymph nodes, joint pain, and sore throat. In some cases, symptoms may be severe and lead to organ and joint damage. The cause of AOSD is unknown, but genetic and other unknown factors may be involved. Diagnosis is based on the symptoms and the results of several blood tests. Other more common conditions need to be ruled out before AOSD can be diagnosed. Treatment involves multiple different types of medications and is focused on controlling the symptoms.
Still’s disease which occurs in children (under the age of 16) is known as systemic onset juvenile rheumatoid arthritis (JRA).
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