This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD).
Alpers syndrome is a progressive neurologic disorder that begins during childhood and is complicated in many instances by serious liver disease. Symptoms include increased muscle tone with exaggerated reflexes (spasticity), seizures, and loss of cognitive ability (dementia).  Most often Alpers syndrome is caused by mutations in the POLG gene. 
For more information, visit GARD.