Laron syndrome

Disease Overview

Laron syndrome is a condition that occurs when the body is unable to utilize growth hormone. It is primarily characterized by short stature. Other signs and symptoms vary but may include reduced muscle strength and endurance; hypoglycemia in infancy; delayed puberty; short limbs (arms and legs); and obesity. It is often caused by changes (mutations) in the GHR gene and is inherited in an autosomal recessive manner. Treatment is focused on improving growth and generally includes injections of insulin-like growth factor 1 (IGF-1).[9719][9720][9721]

Synonyms

• Growth hormone insensitivity syndrome
• Pituitary dwarfism II
• Growth hormone receptor deficiency
• Primary growth hormone resistance
• Primary growth hormone insensitivity
• Laron dwarfism
• Laron type pituitary dwarfism I