Disease Overview

Lipodermatosclerosis refers to changes in the skin of the lower legs. It is a form of panniculitis (inflammation of the layer of fat under the skin). Signs and symptoms include pain, hardening of skin, change in skin color (redness), swelling, and a tapering of the legs above the ankles.[174][8052] The exact underlying cause is unknown; however, it appears to be associated with venous insufficiency and/or obesity. Treatment usually includes compression therapy.[8052]


  • Acute lipodermatosclerosis
  • Hypodermitis sclerodermaformis
  • Sclerosing panniculitis

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National Organization for Rare Disorders