This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD).
Mucopolysaccharidosis type IV (MPS IV), also known as Morquio syndrome, is a rare metabolic condition in which the body is unable to break down long chains of sugar molecules called glycosaminoglycans. As a result, toxic levels of these sugars accumulate in cell structures called lysosomes, leading to the various signs and symptoms associated with the condition. Affected people generally develop features of MPS IV between the ages of 1 and 3. These signs and symptoms may include abnormalities of the skeleton, eyes, heart and respiratory system. There are two forms of MPS IV:
Both forms are inherited in an autosomal recessive manner. Treatment is based on the signs and symptoms present in each person.
For more information, visit GARD.