Neonatal progeroid syndrome

Disease Overview

Neonatal progeroid syndrome is a rare genetic syndrome characterized by an aged appearance at birth. Other signs and symptoms include intrauterine growth restriction, feeding difficulties, distinctive craniofacial features, hypotonia, developmental delay and mild to severe intellectual disability. In most cases, affected infants pass away before age 7 months, but rare reports exist of survival into the teens or early 20s. Although the exact underlying cause of neonatal progeroid syndrome is unknown, it is likely a genetic condition that is inherited in an autosomal recessive manner. Treatment is symptomatic and supportive.[8650][8651][8659]

Synonyms

• Wiedemann-Rautenstrauch syndrome
• Progeroid syndrome neonatal
• Wiedemann Rautenstrauch syndrome