This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD).
Tangier disease is an inherited disorder characterized by significantly reduced levels of high-density lipoprotein (HDL) – the ‘good cholesterol’ – in the blood. Because people with Tangier disease have very low levels of HDL, they have a moderately increased risk of cardiovascular disease. Tangier disease is caused by mutations in the ABCA1 gene. It is inherited in an autosomal recessive pattern.
For more information, visit GARD.