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acute monocytic leukemia

The information provided on this page is for informational purposes only. The National Organization for Rare Disorders (NORD) does not endorse the information presented. The content has been gathered in partnership with the MONDO Disease Ontology. Please consult with a healthcare professional for medical advice and treatment.

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Disease Overview

Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).

Synonyms

  • AML M5
  • AML-M5
  • acute monoblastic leukaemia
  • acute monoblastic leukaemia and acute monocytic leukaemia
  • acute monoblastic leukemia
  • acute monoblastic leukemia and acute monocytic leukemia
  • acute monoblastic/monocytic leukaemia
  • acute monoblastic/monocytic leukemia
  • acute monocytic leukaemia (FAB M5B)
  • acute monocytic leukaemia (FAB M5b)
  • acute monocytic leukaemia without mention of remission
  • acute monocytic leukemia
  • acute monocytic leukemia (FAB M5B)
  • acute monocytic leukemia (FAB M5b)
  • acute monocytic leukemia without mention of remission
  • acute monocytic leukemia, FAB M5
  • acute monocytic leukemia, morphology
  • acute monocytic leukemia, morphology (morphologic abnormality)
  • acute myeloblastic leukaemia type 5
  • acute myeloblastic leukemia type 5
  • leukemia, acute monocytic
  • leukemia, monocytic, malignant
  • monocytic leukaemia
  • monocytic leukemia
  • monocytic leukemia, acute
GARD Disease Summary

The Genetic and Rare Diseases Information Center (GARD) has information and resources for patients, caregivers, and families that may be helpful before and after diagnosis of this condition. GARD is a program of the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH).

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Orphanet

Orphanet has a summary about this condition that may include information on the diagnosis, care, and treatment as well as other resources. Some of the information and resources are available in languages other than English. The summary may include medical terms, so we encourage you to share and discuss this information with your doctor. Orphanet is the French National Institute for Health and Medical Research and the Health Programme of the European Union.

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OMIM

Online Mendelian Inheritance In Man (OMIM) has a summary of published research about this condition and includes references from the medical literature. The summary contains medical and scientific terms, so we encourage you to share and discuss this information with your doctor. OMIM is authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine.

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