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Use the form below to explore NORD's comprehensive rare disease database. Search for detailed information on rare diseases, including NORD's authoritative Rare Disease Reports and data from other reliable sources.
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Fontaine progeroid syndrome

The information provided on this page is for informational purposes only. The National Organization for Rare Disorders (NORD) does not endorse the information presented. The content has been gathered in partnership with the MONDO Disease Ontology. Please consult with a healthcare professional for medical advice and treatment.

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Disease Overview

A rare premature aging syndrome characterized by pre-and postnatal growth retardation, a congenital premature-aged appearance with distinctive craniofacial dysmorphism (wide calvaria with large open anterior fontanel and wide metopic suture, broad forehead, small face, micrognathia), markedly diminished subcutaneous fat, cutis laxa and wrinkled skin, without delay in psychomotor development. Scant, brittle hair, hypoplastic nails and delayed, abnormal dentition, as well as hypoplastic distal phalanges, umbilical hernia and eye abnormalities (myopia/hyperopia, strabismus), are also commonly associated.

Synonyms

  • FPS
  • Fontaine progeroid syndrome
  • GCM syndrome
  • GCMS
  • Gorlin Chaudhry Moss syndrome
  • Gorlin-Chaudhry-Moss Syndrome
  • Gorlin-Chaudhry-Moss syndrome
  • Petty Laxova Wiedemann syndrome
  • Petty syndrome
  • Petty-Laxova-Wiedemann syndrome
  • craniofacial dysostosis, hypertrichosis, Hypoplasia of labia majora, dental and eye anomalies, patent ductus arteriosus, and normal intelligence
  • craniofacial dysostosis, hypertrichosis, hypoplasia of labia majora
  • craniofacial dysostosis, patent ductus arteriosus, hypertrichosis, hypoplasia of labia majora, dental and eye anomalies
  • craniofacial dysostosis-genital, dental, cardiac anomalies syndrome
  • cranofacial dysostosis-hypertrichosis-hypoplasia of labia majora syndrome
  • dental and eye anomalies, patent ductus arteriosus, and normal intelligence
  • dental and eye anomalies-patent ductus arteriosus-normal intelligence syndrome
  • progeroid syndrome Petty type
  • progeroid syndrome congenital Petty type
  • progeroid syndrome, Petty type
  • progeroid syndrome, congenital, Petty type
GARD Disease Summary

The Genetic and Rare Diseases Information Center (GARD) has information and resources for patients, caregivers, and families that may be helpful before and after diagnosis of this condition. GARD is a program of the National Center for Advancing Translational Sciences (NCATS), part of the National Institutes of Health (NIH).

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Orphanet

Orphanet has a summary about this condition that may include information on the diagnosis, care, and treatment as well as other resources. Some of the information and resources are available in languages other than English. The summary may include medical terms, so we encourage you to share and discuss this information with your doctor. Orphanet is the French National Institute for Health and Medical Research and the Health Programme of the European Union.

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OMIM

Online Mendelian Inheritance In Man (OMIM) has a summary of published research about this condition and includes references from the medical literature. The summary contains medical and scientific terms, so we encourage you to share and discuss this information with your doctor. OMIM is authored and edited at the McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine.

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